Computer-Assisted Synthetic Planning: The End of the Beginning.
Identifieur interne : 000C62 ( Main/Exploration ); précédent : 000C61; suivant : 000C63Computer-Assisted Synthetic Planning: The End of the Beginning.
Auteurs : Sara Szymku [Pologne] ; Ewa P. Gajewska [Pologne] ; Tomasz Klucznik [Pologne] ; Karol Molga [Pologne] ; Piotr Dittwald [Pologne] ; Michał Startek [Pologne] ; Michał Bajczyk [Pologne] ; Bartosz A. Grzybowski [Corée du Sud]Source :
- Angewandte Chemie (International ed. in English) [ 1521-3773 ] ; 2016.
Abstract
Exactly half a century has passed since the launch of the first documented research project (1965 Dendral) on computer-assisted organic synthesis. Many more programs were created in the 1970s and 1980s but the enthusiasm of these pioneering days had largely dissipated by the 2000s, and the challenge of teaching the computer how to plan organic syntheses earned itself the reputation of a "mission impossible". This is quite curious given that, in the meantime, computers have "learned" many other skills that had been considered exclusive domains of human intellect and creativity-for example, machines can nowadays play chess better than human world champions and they can compose classical music pleasant to the human ear. Although there have been no similar feats in organic synthesis, this Review argues that to concede defeat would be premature. Indeed, bringing together the combination of modern computational power and algorithms from graph/network theory, chemical rules (with full stereo- and regiochemistry) coded in appropriate formats, and the elements of quantum mechanics, the machine can finally be "taught" how to plan syntheses of non-trivial organic molecules in a matter of seconds to minutes. The Review begins with an overview of some basic theoretical concepts essential for the big-data analysis of chemical syntheses. It progresses to the problem of optimizing pathways involving known reactions. It culminates with discussion of algorithms that allow for a completely de novo and fully automated design of syntheses leading to relatively complex targets, including those that have not been made before. Of course, there are still things to be improved, but computers are finally becoming relevant and helpful to the practice of organic-synthetic planning. Paraphrasing Churchill's famous words after the Allies' first major victory over the Axis forces in Africa, it is not the end, it is not even the beginning of the end, but it is the end of the beginning for the computer-assisted synthesis planning. The machine is here to stay.
DOI: 10.1002/anie.201506101
PubMed: 27062365
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Computer-Assisted Synthetic Planning: The End of the Beginning.</title><author><name sortKey="Szymku, Sara" sort="Szymku, Sara" uniqKey="Szymku S" first="Sara" last="Szymku">Sara Szymku</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224</wicri:regionArea><wicri:noRegion>02-224</wicri:noRegion></affiliation></author><author><name sortKey="Gajewska, Ewa P" sort="Gajewska, Ewa P" uniqKey="Gajewska E" first="Ewa P" last="Gajewska">Ewa P. Gajewska</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224</wicri:regionArea><wicri:noRegion>02-224</wicri:noRegion></affiliation></author><author><name sortKey="Klucznik, Tomasz" sort="Klucznik, Tomasz" uniqKey="Klucznik T" first="Tomasz" last="Klucznik">Tomasz Klucznik</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224</wicri:regionArea><wicri:noRegion>02-224</wicri:noRegion></affiliation></author><author><name sortKey="Molga, Karol" sort="Molga, Karol" uniqKey="Molga K" first="Karol" last="Molga">Karol Molga</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224</wicri:regionArea><wicri:noRegion>02-224</wicri:noRegion></affiliation></author><author><name sortKey="Dittwald, Piotr" sort="Dittwald, Piotr" uniqKey="Dittwald P" first="Piotr" last="Dittwald">Piotr Dittwald</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224</wicri:regionArea><wicri:noRegion>02-224</wicri:noRegion></affiliation></author><author><name sortKey="Startek, Michal" sort="Startek, Michal" uniqKey="Startek M" first="Michał" last="Startek">Michał Startek</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Mathematics, Informatics, and Mechanics, University of Warsaw, Banacha 2, 02-097 Warszawa, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Mathematics, Informatics, and Mechanics, University of Warsaw, Banacha 2, 02-097 Warszawa</wicri:regionArea><wicri:noRegion>02-097 Warszawa</wicri:noRegion></affiliation></author><author><name sortKey="Bajczyk, Michal" sort="Bajczyk, Michal" uniqKey="Bajczyk M" first="Michał" last="Bajczyk">Michał Bajczyk</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224</wicri:regionArea><wicri:noRegion>02-224</wicri:noRegion></affiliation></author><author><name sortKey="Grzybowski, Bartosz A" sort="Grzybowski, Bartosz A" uniqKey="Grzybowski B" first="Bartosz A" last="Grzybowski">Bartosz A. Grzybowski</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224, Poland. nanogrzybowski@gmail.com, grzybor72@unist.ac.kr.</nlm:affiliation><country wicri:rule="url">Corée du Sud</country><wicri:regionArea>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224, Poland. nanogrzybowski@gmail.com</wicri:regionArea><wicri:noRegion>Poland. nanogrzybowski@gmail.com</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Center for Soft and Living Matter of Korea's Institute for Basic Science (IBS), Department of Chemistry, Ulsan National Institute of Science and Technology, 50, UNIST-gil, Eonyang-eup, Ulju-gun, Ulsan, South Korea. nanogrzybowski@gmail.com, grzybor72@unist.ac.kr.</nlm:affiliation><country wicri:rule="url">Corée du Sud</country><wicri:regionArea>Center for Soft and Living Matter of Korea's Institute for Basic Science (IBS), Department of Chemistry, Ulsan National Institute of Science and Technology, 50, UNIST-gil, Eonyang-eup, Ulju-gun, Ulsan, South Korea. nanogrzybowski@gmail.com</wicri:regionArea><wicri:noRegion>South Korea. nanogrzybowski@gmail.com</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27062365</idno><idno type="pmid">27062365</idno><idno type="doi">10.1002/anie.201506101</idno><idno type="wicri:Area/Main/Corpus">000B98</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000B98</idno><idno type="wicri:Area/Main/Curation">000B98</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000B98</idno><idno type="wicri:Area/Main/Exploration">000B98</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Computer-Assisted Synthetic Planning: The End of the Beginning.</title><author><name sortKey="Szymku, Sara" sort="Szymku, Sara" uniqKey="Szymku S" first="Sara" last="Szymku">Sara Szymku</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224</wicri:regionArea><wicri:noRegion>02-224</wicri:noRegion></affiliation></author><author><name sortKey="Gajewska, Ewa P" sort="Gajewska, Ewa P" uniqKey="Gajewska E" first="Ewa P" last="Gajewska">Ewa P. Gajewska</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224</wicri:regionArea><wicri:noRegion>02-224</wicri:noRegion></affiliation></author><author><name sortKey="Klucznik, Tomasz" sort="Klucznik, Tomasz" uniqKey="Klucznik T" first="Tomasz" last="Klucznik">Tomasz Klucznik</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224</wicri:regionArea><wicri:noRegion>02-224</wicri:noRegion></affiliation></author><author><name sortKey="Molga, Karol" sort="Molga, Karol" uniqKey="Molga K" first="Karol" last="Molga">Karol Molga</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224</wicri:regionArea><wicri:noRegion>02-224</wicri:noRegion></affiliation></author><author><name sortKey="Dittwald, Piotr" sort="Dittwald, Piotr" uniqKey="Dittwald P" first="Piotr" last="Dittwald">Piotr Dittwald</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224</wicri:regionArea><wicri:noRegion>02-224</wicri:noRegion></affiliation></author><author><name sortKey="Startek, Michal" sort="Startek, Michal" uniqKey="Startek M" first="Michał" last="Startek">Michał Startek</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Mathematics, Informatics, and Mechanics, University of Warsaw, Banacha 2, 02-097 Warszawa, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Mathematics, Informatics, and Mechanics, University of Warsaw, Banacha 2, 02-097 Warszawa</wicri:regionArea><wicri:noRegion>02-097 Warszawa</wicri:noRegion></affiliation></author><author><name sortKey="Bajczyk, Michal" sort="Bajczyk, Michal" uniqKey="Bajczyk M" first="Michał" last="Bajczyk">Michał Bajczyk</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224</wicri:regionArea><wicri:noRegion>02-224</wicri:noRegion></affiliation></author><author><name sortKey="Grzybowski, Bartosz A" sort="Grzybowski, Bartosz A" uniqKey="Grzybowski B" first="Bartosz A" last="Grzybowski">Bartosz A. Grzybowski</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224, Poland. nanogrzybowski@gmail.com, grzybor72@unist.ac.kr.</nlm:affiliation><country wicri:rule="url">Corée du Sud</country><wicri:regionArea>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224, Poland. nanogrzybowski@gmail.com</wicri:regionArea><wicri:noRegion>Poland. nanogrzybowski@gmail.com</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Center for Soft and Living Matter of Korea's Institute for Basic Science (IBS), Department of Chemistry, Ulsan National Institute of Science and Technology, 50, UNIST-gil, Eonyang-eup, Ulju-gun, Ulsan, South Korea. nanogrzybowski@gmail.com, grzybor72@unist.ac.kr.</nlm:affiliation><country wicri:rule="url">Corée du Sud</country><wicri:regionArea>Center for Soft and Living Matter of Korea's Institute for Basic Science (IBS), Department of Chemistry, Ulsan National Institute of Science and Technology, 50, UNIST-gil, Eonyang-eup, Ulju-gun, Ulsan, South Korea. nanogrzybowski@gmail.com</wicri:regionArea><wicri:noRegion>South Korea. nanogrzybowski@gmail.com</wicri:noRegion></affiliation></author></analytic><series><title level="j">Angewandte Chemie (International ed. in English)</title><idno type="eISSN">1521-3773</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Exactly half a century has passed since the launch of the first documented research project (1965 Dendral) on computer-assisted organic synthesis. Many more programs were created in the 1970s and 1980s but the enthusiasm of these pioneering days had largely dissipated by the 2000s, and the challenge of teaching the computer how to plan organic syntheses earned itself the reputation of a "mission impossible". This is quite curious given that, in the meantime, computers have "learned" many other skills that had been considered exclusive domains of human intellect and creativity-for example, machines can nowadays play chess better than human world champions and they can compose classical music pleasant to the human ear. Although there have been no similar feats in organic synthesis, this Review argues that to concede defeat would be premature. Indeed, bringing together the combination of modern computational power and algorithms from graph/network theory, chemical rules (with full stereo- and regiochemistry) coded in appropriate formats, and the elements of quantum mechanics, the machine can finally be "taught" how to plan syntheses of non-trivial organic molecules in a matter of seconds to minutes. The Review begins with an overview of some basic theoretical concepts essential for the big-data analysis of chemical syntheses. It progresses to the problem of optimizing pathways involving known reactions. It culminates with discussion of algorithms that allow for a completely de novo and fully automated design of syntheses leading to relatively complex targets, including those that have not been made before. Of course, there are still things to be improved, but computers are finally becoming relevant and helpful to the practice of organic-synthetic planning. Paraphrasing Churchill's famous words after the Allies' first major victory over the Axis forces in Africa, it is not the end, it is not even the beginning of the end, but it is the end of the beginning for the computer-assisted synthesis planning. The machine is here to stay.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">27062365</PMID><DateCompleted><Year>2018</Year><Month>07</Month><Day>25</Day></DateCompleted><DateRevised><Year>2018</Year><Month>07</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1521-3773</ISSN><JournalIssue CitedMedium="Internet"><Volume>55</Volume><Issue>20</Issue><PubDate><Year>2016</Year><Month>05</Month><Day>10</Day></PubDate></JournalIssue><Title>Angewandte Chemie (International ed. in English)</Title><ISOAbbreviation>Angew Chem Int Ed Engl</ISOAbbreviation></Journal><ArticleTitle>Computer-Assisted Synthetic Planning: The End of the Beginning.</ArticleTitle><Pagination><MedlinePgn>5904-37</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/anie.201506101</ELocationID><Abstract><AbstractText>Exactly half a century has passed since the launch of the first documented research project (1965 Dendral) on computer-assisted organic synthesis. Many more programs were created in the 1970s and 1980s but the enthusiasm of these pioneering days had largely dissipated by the 2000s, and the challenge of teaching the computer how to plan organic syntheses earned itself the reputation of a "mission impossible". This is quite curious given that, in the meantime, computers have "learned" many other skills that had been considered exclusive domains of human intellect and creativity-for example, machines can nowadays play chess better than human world champions and they can compose classical music pleasant to the human ear. Although there have been no similar feats in organic synthesis, this Review argues that to concede defeat would be premature. Indeed, bringing together the combination of modern computational power and algorithms from graph/network theory, chemical rules (with full stereo- and regiochemistry) coded in appropriate formats, and the elements of quantum mechanics, the machine can finally be "taught" how to plan syntheses of non-trivial organic molecules in a matter of seconds to minutes. The Review begins with an overview of some basic theoretical concepts essential for the big-data analysis of chemical syntheses. It progresses to the problem of optimizing pathways involving known reactions. It culminates with discussion of algorithms that allow for a completely de novo and fully automated design of syntheses leading to relatively complex targets, including those that have not been made before. Of course, there are still things to be improved, but computers are finally becoming relevant and helpful to the practice of organic-synthetic planning. Paraphrasing Churchill's famous words after the Allies' first major victory over the Axis forces in Africa, it is not the end, it is not even the beginning of the end, but it is the end of the beginning for the computer-assisted synthesis planning. The machine is here to stay.</AbstractText><CopyrightInformation>© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Szymkuć</LastName><ForeName>Sara</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gajewska</LastName><ForeName>Ewa P</ForeName><Initials>EP</Initials><AffiliationInfo><Affiliation>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klucznik</LastName><ForeName>Tomasz</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Molga</LastName><ForeName>Karol</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dittwald</LastName><ForeName>Piotr</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Startek</LastName><ForeName>Michał</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Faculty of Mathematics, Informatics, and Mechanics, University of Warsaw, Banacha 2, 02-097 Warszawa, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bajczyk</LastName><ForeName>Michał</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grzybowski</LastName><ForeName>Bartosz A</ForeName><Initials>BA</Initials><AffiliationInfo><Affiliation>Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, 02-224, Poland. nanogrzybowski@gmail.com, grzybor72@unist.ac.kr.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Soft and Living Matter of Korea's Institute for Basic Science (IBS), Department of Chemistry, Ulsan National Institute of Science and Technology, 50, UNIST-gil, Eonyang-eup, Ulju-gun, Ulsan, South Korea. nanogrzybowski@gmail.com, grzybor72@unist.ac.kr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>04</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Angew Chem Int Ed Engl</MedlineTA><NlmUniqueID>0370543</NlmUniqueID><ISSNLinking>1433-7851</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Chematica</Keyword><Keyword MajorTopicYN="Y">algorithms</Keyword><Keyword MajorTopicYN="Y">computers</Keyword><Keyword MajorTopicYN="Y">networks</Keyword><Keyword MajorTopicYN="Y">organic synthesis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>07</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>09</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>4</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>4</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>4</Month><Day>12</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27062365</ArticleId><ArticleId IdType="doi">10.1002/anie.201506101</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Corée du Sud</li><li>Pologne</li></country></list><tree><country name="Pologne"><noRegion><name sortKey="Szymku, Sara" sort="Szymku, Sara" uniqKey="Szymku S" first="Sara" last="Szymku">Sara Szymku</name></noRegion><name sortKey="Bajczyk, Michal" sort="Bajczyk, Michal" uniqKey="Bajczyk M" first="Michał" last="Bajczyk">Michał Bajczyk</name><name sortKey="Dittwald, Piotr" sort="Dittwald, Piotr" uniqKey="Dittwald P" first="Piotr" last="Dittwald">Piotr Dittwald</name><name sortKey="Gajewska, Ewa P" sort="Gajewska, Ewa P" uniqKey="Gajewska E" first="Ewa P" last="Gajewska">Ewa P. Gajewska</name><name sortKey="Klucznik, Tomasz" sort="Klucznik, Tomasz" uniqKey="Klucznik T" first="Tomasz" last="Klucznik">Tomasz Klucznik</name><name sortKey="Molga, Karol" sort="Molga, Karol" uniqKey="Molga K" first="Karol" last="Molga">Karol Molga</name><name sortKey="Startek, Michal" sort="Startek, Michal" uniqKey="Startek M" first="Michał" last="Startek">Michał Startek</name></country><country name="Corée du Sud"><noRegion><name sortKey="Grzybowski, Bartosz A" sort="Grzybowski, Bartosz A" uniqKey="Grzybowski B" first="Bartosz A" last="Grzybowski">Bartosz A. Grzybowski</name></noRegion><name sortKey="Grzybowski, Bartosz A" sort="Grzybowski, Bartosz A" uniqKey="Grzybowski B" first="Bartosz A" last="Grzybowski">Bartosz A. Grzybowski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SanteMusiqueV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C62 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000C62 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SanteMusiqueV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:27062365
|texte= Computer-Assisted Synthetic Planning: The End of the Beginning.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27062365" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SanteMusiqueV1
| This area was generated with Dilib version V0.6.38. |  |